z-logo
Premium
Relationships between oral infections and blood glucose concentrations or H b A 1c levels in normal and diabetic rats
Author(s) -
Cintra L. T. A.,
Samuel R. O.,
Facundo A. C. S.,
Prieto A. K. C.,
Sumida D. H.,
Bomfim S. R. M.,
Souza J. C.,
DezanJúnior E.,
GomesFilho J. E.
Publication year - 2014
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/iej.12136
Subject(s) - periodontitis , medicine , diabetes mellitus , dental alveolus , streptozotocin , endocrinology , bone resorption , resorption , dentistry , gastroenterology
Aim To measure glycosylated haemoglobin ( H b A 1c) in a diabetic model as a means of investigating apical periodontitis and periodontal disease for their effects on both blood glucose concentrations and long‐term glycaemic control. Methodology Wistar rats ( n  = 80) were assigned to one of eight groups (10 animals/group): control ( G 1), apical periodontitis ( G 2), periodontal disease ( G 3), apical periodontitis and periodontal disease ( G 4), diabetic ( G 5), diabetic with apical periodontitis ( G 6), diabetic with periodontal disease ( G 7) and diabetic with apical periodontitis and periodontal disease ( G 8). A diabetic state was induced with streptozotocin. Apical periodontitis was induced by dental exposure to the oral environment. Periodontal disease was induced by periodontal ligature. Blood glucose concentrations were measured at 0, 6, 30 and 60 days. After euthanization, rat maxillae were excised and processed for histopathology and for measurement of H b A 1c levels by ion exchange chromatography. Data were tabulated and subject to statistical analysis ( P  < 0.05). Results The inflammatory infiltrate and alveolar bone resorption were more severe in diabetic rats ( P  < 0.05). Diabetic rats exhibited higher levels of H b A 1c independent of apical periodontitis or periodontal disease ( P  < 0.05). However, the presence of oral infections in diabetic rats was associated with increased blood glucose concentrations ( P  < 0.05). Conclusions Oral infections affect glycaemic conditions in diabetic rats and increase H b A 1c levels in normoglycaemic or diabetic rats.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here