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Biocompatibility of B io A ggregate and mineral trioxide aggregate on the liver and kidney
Author(s) -
Khalil W. A.,
Eid N. F.
Publication year - 2013
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/iej.12050
Subject(s) - mineral trioxide aggregate , kidney , analysis of variance , medicine , post hoc , gastroenterology , dentistry
Aim To investigate and compare the systemic toxic effect of D ia R oot B io A ggregate and grey P ro R oot M ineral trioxide aggregate ( MTA ) on the liver and kidney after 7 and 30 days. Methodology Forty‐two white albino rats were divided into two main groups. Group (1), considered the control group ( n = 18), was further divided into two subgroups. The negative control subgroup ( n = 6) received no treatment. The empty tube subgroup ( n = 12) received empty sterile T eflon tubes. In Group (2), considered the experimental group ( n = 24), the rats were divided equally into two subgroups. One subgroup received MTA , whilst the other received B io A ggregate. The materials in the T eflon tubes were implanted subcutaneously in the dorsal side of the rats. Blood samples were taken to investigate the change of kidney and liver functions on day 7 and day 30. The liver and kidney organs were subjected to histopathological examination and calculation of the number of inflammatory cells. Data analysis was performed using one‐way anova with post hoc multiple comparisons with the T ukey's test. Student's t ‐test was used to compare the changes in liver and kidney functions amongst the groups. Results On day 7, a significantly more severe inflammatory reaction was observed in both experimental subgroups compared with the control ( P < 0.05); the severity decreased after 30 days. The kidney functions were not affected after 7 days but had subsequently increased after 30 days ( P < 0.001). Liver functions increased after 7 days and had decreased in the B io A ggregate subgroup after 30 days, whilst in the MTA subgroup, a continuous increase in the level of liver function was observed. Conclusions Mineral trioxide aggregate had adverse effects on the liver and kidney that were significantly more severe than B io A ggregate but with no permanent damage.