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Boric acid as an adjunct to periodontal therapy: A systematic review and meta‐analysis
Author(s) -
Bashir Nasir Zeeshan,
Krstic Milan
Publication year - 2021
Publication title -
international journal of dental hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.674
H-Index - 38
eISSN - 1601-5037
pISSN - 1601-5029
DOI - 10.1111/idh.12487
Subject(s) - medicine , placebo , meta analysis , adverse effect , adjunct , randomized controlled trial , boric acid , periodontitis , dentistry , cochrane library , mean difference , web of science , confidence interval , linguistics , philosophy , physics , alternative medicine , pathology , nuclear physics
Objective To evaluate the efficacy of boric acid as an adjunct to non‐surgical periodontal therapy, in comparison with a placebo adjunct, in terms of changes in probing pocket depth (PPD) and clinical attachment level (CAL), in patients with periodontitis. Methods Four electronic databases were searched from inception to May 2020 (PubMed, Cochrane CENTRAL, EMBASE via OVID and Web of Science). Clinical outcomes were extracted, pooled and meta‐analyses conducted using mean difference with standard deviations. Results For PPD, a mean additional reduction of 0.58 mm (95% CI: −0.03–1.19 mm, p = 0.06) was observed at 3 months and a mean additional reduction of 1.18 mm (95% CI: 0.97–1.40 mm, p < 0.05) at 6 months, compared with placebo. For CAL, a mean additional gain of 0.62 mm (95% CI: −0.07–1.32 mm, p = 0.08) was observed at 3 months and a mean additional gain of 1.24 mm (95% CI: 0.89–1.58 mm, p < 0.05) at 6 months, compared with placebo. No adverse events were reported in any studies. Conclusions The adjunctive use of boric acid in non‐surgical periodontal therapy results in improved treatment outcomes at 3 and 6 months, with no adverse events reported.