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Effects of petrolatum, a petrolatum depositing body wash and a regular body wash on biomarkers and biophysical properties of the stratum corneum
Author(s) -
Wei Karl,
Stella Ching,
Wehmeyer Kenneth,
Christman Jeremy,
Altemeier Amy,
Spruell Russell,
Wimalasena Rohan,
Fadayel Gina,
Wickett R. Randall
Publication year - 2021
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12684
Subject(s) - stratum corneum , involucrin , chemistry , transepidermal water loss , dry skin , skin care , dermatology , medicine , pathology , keratinocyte , biochemistry , organic chemistry , in vitro
Background An important trend in the personal care industry involves the development of body wash products that not only clean the skin without damage but deposit conditioning ingredients to improve skin barrier function. Objective The objective of this study was to develop skin biomarker measures to quantify the treatment effects of body wash products. Methods We employed analysis of structural proteins (keratin 1,10,11 and involucrin), a natural moisturizing factor (pyrrolidone carboxylic acid) and an inflammatory mediator (IL‐1ra/IL‐1α) from adhesive discs with dry skin grading, TEWL and capacitance measurements to compare the effects of direct application of petrolatum, a high petrolatum depositing body wash, and a regular body wash on dry leg skin in a standard leg‐wash treatment protocol. Results High depositing body wash and petrolatum had positive effects on stratum corneum barrier function as judged by biomarker analysis, biophysical measurements and skin grading compared to the regular body wash product. Conclusions The results clearly indicate that a combination of biomarker and biophysical property measurements is effective for determining the skin benefits of moisturizing body wash products.