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Topical monomethylsilanetriol can deliver silicon to the viable skin
Author(s) -
Polonini H. C.,
Ferreira A. O.,
Brandão M. A. F.,
Raposo N. R. B.
Publication year - 2019
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12552
Subject(s) - hacat , dermis , epidermis (zoology) , chemistry , antioxidant , permeation , viability assay , cytotoxicity , food science , pharmacology , dermatology , microbiology and biotechnology , cell , in vitro , biochemistry , medicine , biology , anatomy , membrane
Abstract Objective Organic silicon has been linked to positive effects on the skin rejuvenation, mainly by the oral route. Thus, the main objective of the present study was to assess whether monomethylsilanetriol ( MMST , a source of organic silicon) can deliver silicon to the epidermis and dermis, when applied topically in a cream. Once the hypothesis was confirmed, the present study also evaluated whether the product was toxic to keratinocytes; additionally, its possible antioxidant activity was assessed. Methods The ex vivo skin permeation profile was determined using human skin in Franz‐cells equipment; cytotoxicity was assessed using HaCaT keratinocytes. Antioxidant capacity was determined as scavenging activity, measured according to the 1,1‐diphenyl‐2‐picrylhydrazil free radical method. Results The permeation percentage was almost 60% of the applied MMST , with a large quantity of drug found in the viable epidermis and dermis. The cell viability assay showed no significant difference in the percentage of viable keratinocytes among the treated groups at the doses used. In terms of antioxidant activity, the IC 50 value obtained was 2400 μg mL −1 . Low antioxidant activity, negligible toxicity for keratinocytes and a significant percentage of permeation were observed. Conclusion We provide evidence that MMST applied topically can deliver silicon to the skin in biorelevant levels for cosmetic purposes.