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18β‐Glycyrrhetinic acid: its core biological properties and dermatological applications
Author(s) -
Kowalska A.,
KalinowskaLis U.
Publication year - 2019
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12548
Subject(s) - chemistry , glycyrrhizin , antimicrobial , traditional medicine , atopic dermatitis , pharmacology , medicine , dermatology , organic chemistry
Recently, attention has been focused on identifying natural herbal compounds with high biological activity, especially antioxidative, anti‐inflammatory and antimicrobial properties, for preventing and controlling various skin conditions, including inflammation‐related diseases such as atopic dermatitis and UV‐induced skin photoaging. One key active plant ingredient is 18β‐glycyrrhetinic acid (GA), the main metabolite of glycyrrhizin (GL), obtained from licorice root. The review examines the valuable biological properties of GA, particularly those playing key roles in the treatment of various dermatological disorders in humans. The review highlights the key anti‐inflammatory, antioxidant and antimicrobial properties of GA and its toxicity towards normal cells lines. It also examines the physicochemical properties of GA and presents methods of increasing its penetration through the stratum corneum and bioaccumulation with the use of modern delivery systems such as liposomes and nanoemulsions.