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Reinforcement of barrier function – skin repair formulations to deliver physiological lipids into skin
Author(s) -
Zhang Z.,
Lukic M.,
Savic S.,
Lunter D. J.
Publication year - 2018
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12491
Subject(s) - transepidermal water loss , stratum corneum , ex vivo , barrier function , in vivo , chemistry , skin repair , skin aging , biomedical engineering , dermatology , surgery , medicine , biochemistry , in vitro , wound healing , pathology , biology , microbiology and biotechnology
Abstract Objective The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. Methods Physiological cholesterol and linoleic acid were incorporated into basic cream and non‐ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid‐deficient skin samples and confocal Raman microspectroscopy. A 7‐day in vivo study was performed on volunteers to study the repairing efficacy. Results Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid‐deficient skin in ex vivo study. Twice‐a‐day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. Conclusion The skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum.