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Vichy Thermal Spring Water ( VTSW ), a cosmetic ingredient of potential interest in the frame of skin ageing exposome: an in vitro study
Author(s) -
Tacheau C.,
Weisgerber F.,
Fagot D.,
Bastien P.,
Verdier M. P.,
Liboutet M.,
Sore G.,
Bernard B. A.
Publication year - 2018
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12470
Subject(s) - keratinocyte , biology , in vitro , ageing , microbiology and biotechnology , genetics
Objective To study the effects of the very high minerality Vichy Thermal Spring Water ( VTSW ) on human keratinocytes grown in vitro . Methods The effect of VTSW was monitored by full genome transcriptomic technology and immunofluorescence microscopy. Results In the presence of 50% VTSW , the expression of a number of skin homoeostasis‐related genes is increased, specifically with respect to dermal‐epidermal junction, epidermal cohesion and communication, keratinocyte proliferation–differentiation balance, antioxidant mechanisms and DNA repair. Conclusion This work suggests that VTSW could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome.