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Optimization of the method of the content‐containing interaction evaluation for cosmetic products by gas chromatography–mass spectrometry
Author(s) -
Charron C.,
De Vaugelade S.,
Richard F.,
Largitte A.,
Pirnay S.
Publication year - 2018
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12460
Subject(s) - chromatography , extraction (chemistry) , mass spectrometry , chemistry , repeatability , plastic packaging , gas chromatography , gas chromatography–mass spectrometry , contamination , calibration curve , detection limit , materials science , ecology , composite material , biology
In July 2013, the European Regulation ( EC ) No 1223/2009 came into effect in order to secure cosmetic products. The content‐containing interaction between the packaging and the product must be considered for the safety assessment. Indeed, some compounds are able to migrate from the packaging to the product and may be harmful to the consumer health. This is why a first test was established by EXPERTOX laboratory in 2012 to deal with this new regulation. A new analytical method was developed and validated for the quantification of 23 substances able to migrate from the packaging to the product. It was applied on a plastic packaging with the five simulants of migration. To evaluate the content‐containing interaction, a gas chromatography‐mass spectrometry method was developed and validated. Liquid–liquid extraction was used to extract contaminants (thirteen phthalates and ten substances of very high concern) from migration simulants. Calibration curves showed good linearity regression from 2 to 50 μg mL −1 for nineteen molecules and from 5 to 45 μg mL −1 for the others. The limits of quantification were respectively 2 and 5 μg mL −1 . The accuracy, precision, repeatability of the analytical method and extraction yields were acceptable. No molecule was found in simulants of migration, so the potential contaminants present in the packaging did not migrate. A gas chromatography‐mass spectrometry method and liquid‐liquid extraction were validated for 23 molecules and can be used for the evaluation of the content‐containing interaction of cosmetic products. Both quantification and extraction procedures are more robust and faster than previous method.