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Skin delivery of hydrophilic molecules from liposomes and polysaccharide‐coated liposomes
Author(s) -
Belhaj N.,
ArabTehrany E.,
Loing E.,
Bézivin C.
Publication year - 2017
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12394
Subject(s) - liposome , bioavailability , chemistry , polysaccharide , penetration (warfare) , permeation , chromatography , membrane , pharmacology , biochemistry , medicine , operations research , engineering
Objectives Liposomes are commonly used in cosmetic formulations to increase the bioavailability of active ingredients. We have previously shown that polysaccharide coating of liposomes improves their resistance to surfactants and electrolytes. In the current study, we have assessed the impact of coating on the skin penetration enhancer properties of liposomes. Methods The physicochemical properties of coated liposomes (Ionosomes™) were evaluated before and after encapsulation of two different hydrophilic molecules (caffeine and a hexapeptide), and compared to those observed with non‐coated liposomes. Moreover, in vitro permeation experiments were performed using Franz™ ‐ modified diffusion cells, with normal human skin as membranes. Results Results showed that both coated and non‐coated liposomes significantly improved the bioavailability of hydrophilic active molecules in skin, compared to reference solutions. Although liposome coating slightly reduced entrapment efficiency, the delivery of active molecules was not adversely affected by the process. In conclusion, polysaccharide coating of liposomes allows for better protection of their integrity without compromising the skin bioavailability of the active molecules that they convoy.