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Randomized, double‐blinded, vehicle‐controlled, split‐face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing
Author(s) -
Berardesca E.,
Ardigo M.,
Cameli N.,
Mariano M.,
Agozzino M.,
Matts P.J.
Publication year - 2015
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12237
Subject(s) - transepidermal water loss , photoaging , dermatology , stratum corneum , silk , skin aging , medicine , biomedical engineering , surgery , materials science , pathology , composite material
Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin ( GSS ) complex on biophysical parameters related to skin ageing. Methods A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face study among 40 female subjects aged 40–70. Endpoints measured included expert grades of skin condition, stratum corneum ( SC ) hydration, SC barrier function, elasticity and surface topography. Results The GSS complex produced significant single‐variable ( P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. Conclusion The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.