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Inhibition of melanogenesis by β ‐caryophyllene from lime mint essential oil in mouse B16 melanoma cells
Author(s) -
Yang C.H.,
Huang Y.C.,
Tsai M.L.,
Cheng C.Y.,
Liu L.L.,
Yen Y.W.,
Chen W.L.
Publication year - 2015
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12224
Subject(s) - essential oil , caryophyllene , chemistry , melanin , lime , limonene , matricaria chamomilla , eugenol , microphthalmia associated transcription factor , food science , horticulture , biochemistry , tyrosinase , biology , organic chemistry , paleontology , enzyme
Synopsis Objective Volatile essential oils of mint species are used for cosmetics and in skin care products. In this study, we evaluated the main chemical components of the lime mint and the anti‐melanogenic properties of its main components. Methods The essential oil was analysed by gas chromatography–mass spectrometry ( GC / MS ). The anti‐melanogenic effects of mint essential oil and β ‐caryophyllene were investigated in B16F10 murine melanoma cells. Results The main components of lime mint essential oil were found to be D‐limonene (41.10%), D‐carvone (8.58%), δ ‐selinene (6.73%) and β ‐caryophyllene (6.24%). The lime mint essential oil reduced melanin production in a dose‐dependent manner in murine B16F10 cells. β ‐Caryophyllene, one of the main compounds in lime mint essential oil, could reduce melanogenesis by down‐regulating the expression of MITF , TRP ‐1, TRP ‐2 and tyrosinase, resulting in a decrease in melanin content decrease. Conclusion These results reveal that lime mint essential oil and β ‐caryophyllene are considered to be valuable as potential skin‐whitening agents.