Preparation and evaluation of novel octylmethoxycinnamate‐loaded solid lipid nanoparticles | Zendy

Liu X.h. | Zendy; Liang X.z. | Zendy; Fang X. | Zendy; Zhang W.P. | Zendy

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Preparation and evaluation of novel octylmethoxycinnamate‐loaded solid lipid nanoparticles

Author(s) -

Liu X.h.,

Liang X.z.,

Fang X.,

Zhang W.P.

Publication year - 2015

Publication title -

international journal of cosmetic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.532

H-Index - 62

eISSN - 1468-2494

pISSN - 0142-5463

DOI - 10.1111/ics.12216

Subject(s) - solid lipid nanoparticle , differential scanning calorimetry , dispersity , sonication , particle size , absorbance , nanoparticle , fourier transform infrared spectroscopy , scanning electron microscope , materials science , emulsion , chemistry , chemical engineering , nuclear chemistry , analytical chemistry (journal) , chromatography , nanotechnology , polymer chemistry , organic chemistry , composite material , physics , engineering , thermodynamics

Synopsis Objective Octylmethoxycinnamate ( OMC )‐loaded solid lipid nanoparticles ( SLN s) were prepared by ultrasonic emulsification method. Effects of process variables and formulation composition were investigated on particle size and polydispersity index ( PI ), and the UV absorbance. Effect of OMC concentration on entrapment efficiency (EE) was also studied. Methods The optimal formulation was characterized and evaluated by environment emission scanning electron microscopy ( ESEM ), differential scanning calorimetry ( DSC ) and Fourier transform infrared spectroscopy ( FT ‐ IR ). In addition, the degradations of OMC from SLN s and OMC conventional emulsion were compared. Results The composition of optimal formulation was determined as 5% (w/w) of solid lipid, 7% (w/w) of emulsifier and 9% of loaded OMC , resulting in a particle size of 392.8 nm, and EE of 88.73%, LD of 38.05% under the preparation condition of 6 min of sonication, 400 W of sonication power. ESEM study showed spherical particles with smooth surface. DSC studies indicated OMC encapsulation within the nanoparticle matrix. The characteristic peaks for OMC ‐ SLN s stood at 1710, 1604, 1513, 1465 and 830.3 cm −1 . The degradation rate of OMC was decreased when using SLN s formulations compared to conventional emulsion. Conclusion Hence, the developed SLN s can be used as sunscreen carrier for improve the stability.

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