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Metal oxide‐coating PMMA or Talc as a new IR blocker inhibits IR ‐induced decrease of collagens in human dermal fibroblasts
Author(s) -
Nam J.J.,
Lee K.E.,
Kim Y. J.
Publication year - 2015
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12214
Subject(s) - chemistry , nuclear chemistry , metal , fibroblast , oxide , microbiology and biotechnology , biochemistry , in vitro , organic chemistry , biology
Synopsis Objectives The purpose of this study was whether P/M or T/M inhibits IR ‐induced decrease of collagens in human dermal fibroblasts, using P/M or T/M blocked near‐ IR ( NIR ) transmittance significantly in spectrophotometer measurement. Methods As metal oxides are effective inorganic molecules for intercepting IR radiation, we have developed metal oxide‐coating PMMA (P/M) or Talc (T/M) as a new IR blocker. Inhibitory effect of the new IR blocker on collagen degradation was measured by gene and protein expressions of procollagens and MMP s, respectively, in IR ‐irradiated Hs68 cell line. Results Using P/M or T/M inhibited IR ‐induced increases of MMP ‐1, MMP ‐3 and MMP ‐9, and IR ‐induced decreases of type 1 and 4 procollagen in a dose‐dependent manner in dermal fibroblasts. In addition, using both P/M and T/M blocked the increase of cell media temperature induced by IR lamp. Conclusion The results suggest that P/M or T/M can inhibit decrease of collagens by blocking IR ‐induced heat transmission in human dermal fibroblasts.