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Preliminary 1 month stability screening of cosmetic multiple emulsions ( W / O / W ) prepared using cetyl dimethicone copolyol and P olysorbate 80
Author(s) -
Khan H.,
Akhtar N.,
Mahmood T.,
Jameel A.,
Mohsin S.
Publication year - 2015
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/ics.12172
Subject(s) - emulsion , chromatography , chemistry , polyvinyl alcohol , rheology , viscosity , ingredient , polysorbate , active ingredient , pulmonary surfactant , materials science , organic chemistry , food science , composite material , bioinformatics , biochemistry , biology
Abstract Objectives The objective of this work was to develop W/O/W emulsions with different concentration of paraffin oil, lipophilic (cetyl dimethicone copolyol) and hydrophilic emulsifiers (polysorbate 80) and to check their stability at different storage conditions. Methods Approximately, 20 formulations (W/O/W) multiple emulsions were prepared, and their stability was checked at different storage conditions for the period of 30 days. Stability of some multiple emulsions ME 12, ME 13, ME 14, ME 19 and ME 20 was also checked with carbomer as viscosity‐enhancing agent. Microscopic analysis for droplet size determination and rheological characterization of most stable multiple emulsions, that is, ME 20 were also performed. Results It was observed that stability of multiple emulsion increases with the addition of gelling agent. Formulation ( ME 20) with 13.6% paraffin oil, 2.4% cetyl dimethicone copolyol and 0.8% polysorbate 80 was found more stable at 25°C and 40°C for the period of 30 days. Rheological analysis indicated a decrease in viscosity with the passage of time, while droplet size analysis indicated an increase in droplet size with the passage of time. Conclusion As a conclusion of this work, a stable multiple emulsion with 13.6% paraffin oil, 2.4% cetyl dimethicone copolyol and 0.8% polysorbate 80 can be formulated and can be further studied for any active ingredient for cosmetic purposes.