Open AccessAssociation analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population
Author(s) -
Zhang Lili,
Zhong Xianjiang,
An Zhiguo,
Han Shuxian,
Luo Xiao,
Shi Yongyong,
Yi Qizhong
Publication year - 2014
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/hrd2.00045
Subject(s) - schizophrenia (object oriented programming) , biology , genotyping , genotype , bonferroni correction , pathogenesis , taqman , genetic association , population , genetics , gene , bioinformatics , psychiatry , medicine , single nucleotide polymorphism , immunology , real time polymerase chain reaction , statistics , mathematics , environmental health
GRM8 is a schizophrenia candidate gene that is also thought to be involved in the glutamate pathway, which is very important in the pathogenesis of schizophrenia. In this study, we aim to investigate the association between GRM8 and schizophrenia in the Uygur Chinese population. Rs2237748 and rs2299472, located in the GRM8 gene, were selected for genotyping in a set of Uygur Chinese case‐control samples, which included 723 cases and 561 controls, using TaqMan assays and capillary sequencing. The statistical analysis was carried out using the online software program SHEsis, and a meta‐analysis was carried out to identify other relevant studies using Review Manager 5. We found that the rs2299472 genotype was significantly associated with schizophrenia (P = 0.015, P = 0.030, after Bonferroni correction). The frequency of the CC genotype was higher in the schizophrenic patients (P = 0.008), and the frequency of the AC genotype was lower (P = 0.008). Furthermore, the meta‐analysis incorporating the previous and current studies also showed that rs2299472 is associated with schizophrenia. This study indicates that the GRM8 gene may play an important role in the pathogenesis of schizophrenia.