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Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls
Author(s) -
KrebsDemmer L,
Ronit A,
Sigvardsen PE,
Lebech AM,
Gerstoft J,
Knudsen AD,
Fuchs A,
Kühl JT,
Nordestgaard BG,
Kofoed KF,
Nielsen SD
Publication year - 2020
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12916
Subject(s) - medicine , cardiology , human immunodeficiency virus (hiv) , body surface area , diastole , blood pressure , immunology
Objectives People living with HIV (PLWH) have increased risk of cardiovascular diseases compared with uninfected populations. We assessed structural cardiac abnormalities and their associated risk factors in well‐treated PLWH and uninfected controls using multidetector computed tomography (MDCT). Methods People living with HIV and age‐ and sex‐matched uninfected controls underwent MDCT to determine left atrial volume (LAV), left ventricular diastolic volume (LVDV), right ventricular diastolic volume (RVDV) and left ventricular mass (LVM). All outcomes were indexed to body surface area (BSA) (LAVi, LVDVi, RVDVi and LVMi). Results A total of 592 PLWH and 1184 uninfected controls were included in the study. PLWH had smaller mean (SD) LAVi [40 (8) vs . 41 (9) mL/m 2 ; P = 0.002] and LVDVi [61 (13) vs . 65 (14) mL/m 2 ; P < 0.001] but larger RVDVi [89 (18) vs . 86 (17) mL/m 2 ; P < 0.001] than uninfected controls. HIV was independently associated with 7 mL (95% CI: −10 to −3) smaller LVDV, and with 12 mL (95% CI: 8–16) larger RVDV, and 4 g (95% CI: 1–6) larger LVM after adjustment for cardiovascular risk factors and BSA. Large RVDV in PLWH was not associated with obstructive lung function. Conclusions HIV was independently associated with smaller LVDV and larger RVDV and LVM. Alterations in cardiac chamber volumes in PLWH were mainly minor. The clinical impact of these findings is uncertain, but it seems unlikely that alterations in cardiac chamber volumes explain the increased burden of cardiovascular disease previously observed in PLWH.