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Post‐exposure prophylaxis following consented sexual exposure: impact of national recommendations on user profile, drug regimens and estimates of averted HIV infections
Author(s) -
Pereira IO,
Pascom ARP,
Mosimann G,
Barros Perini F,
Coelho RA,
Rick F,
Benzaken A,
AvelinoSilva VI
Publication year - 2020
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12825
Subject(s) - medicine , pre exposure prophylaxis , post exposure prophylaxis , context (archaeology) , human immunodeficiency virus (hiv) , christian ministry , outreach , medical prescription , reproductive health , men who have sex with men , environmental health , family medicine , population , pharmacology , paleontology , philosophy , theology , syphilis , political science , law , biology
Objectives The aim of the study was to describe the characteristics, impact and outreach of post‐exposure prophylaxis (PEP) for sexual exposure in Brazil. Methods We used secondary data from the Brazilian Ministry of Health to describe the impact of national guidelines on the frequency of prescription, user profile and antiretroviral regimens. We also estimated the number of potentially averted HIV infections attributable to PEP for consented sexual exposure between 2009 and 2017. Results A total of 260 457 PEP regimens were prescribed to individuals ≥ 14 years old; 104 613 (40.2%) were prescribed for consented sexual exposure, with an increasing frequency since 2011. Drugs used in PEP regimens underwent significant modifications during the period, reflecting national recommendations. We estimated that there were up to 3138 potentially averted HIV infections attributable to PEP for consented sexual exposure between 2009 and 2017. Conclusions In the context of a combined HIV prevention strategy, PEP is still an essential tool for individuals for whom other methods are contraindicated or fail to be applied.