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Efficacy and tolerability of lamivudine plus dolutegravir as a switch strategy in a multicentre cohort of patients with suppressed HIV ‐1 replication
Author(s) -
Borghetti A,
Baldin G,
Lombardi F,
Ciccullo A,
Capetti A,
Rusconi S,
Sterrantino G,
Latini A,
Cossu MV,
Gagliardini R,
De Luca A,
Di Giambenedetto S
Publication year - 2018
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12611
Subject(s) - dolutegravir , lamivudine , medicine , tolerability , cohort , discontinuation , viral load , renal function , gastroenterology , virology , adverse effect , human immunodeficiency virus (hiv) , antiretroviral therapy , virus , hepatitis b virus
Objectives We evaluated the efficacy and tolerability of lamivudine + dolutegravir in a cohort of HIV ‐1 infected, treatment‐experienced patients with undetectable HIV ‐ RNA . Methods Time to treatment discontinuation ( TD ) and virological failure ( VF ) and their predictors were assessed in a multicenter cohort of HIV ‐1 infected patients, starting lamivudine + dolutegravir after reaching viral suppression. Secondary objective was the evaluation of changes in lipid profile, renal and immunological functions at week 48. Results We enrolled 206 patients (72.8% male, with 51 years median age), who mainly switched their antiretroviral therapy for simplification (32.5%) or drug toxicity (54.5%). The estimated probability of maintaining virological suppression at 48 and 96 weeks was 98.2% and 95.1%, respectively. VF was independently predicted by cumulative time on antiretroviral therapy. The estimated probability of remaining on lamivudine plus dolutegravir was 86.7% and 80.5% at week 48 and 96, respectively. A significant improvement in immunological function ( CD 4 count and CD 4/ CD 8 ratio) was evidenced at week 48, as well as a decrease in total cholesterol/ HDL ratio, triglycerides and estimated glomerular filtration rate. Conclusions Lamivudine plus dolutegravir was effective in maintaining viral suppression in our cohort and led to an improvement in metabolic and immunologic functions.