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Bone quality assessed using quantitative ultrasound at the distal radius does not differ in antiretroviral therapy‐naïve HIV ‐positive and HIV ‐negative Rwandan women
Author(s) -
Mutimura E,
Shi Q,
Hoover DR,
Anastos K,
Rudakemwa E,
Dusingize JC,
Sinabye JD,
Yin MT
Publication year - 2016
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12376
Subject(s) - medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , body mass index , incidence (geometry) , ultrasound , viral load , immunology , radiology , physics , optics
Objectives The incidence of fractures appears to be increased in HIV ‐infected individuals. Methods We assessed bone quality using quantitative ultrasound ( QUS ) in HIV ‐infected and uninfected Rwandan women. A Sunlight Omnisense 7000 QUS was used to measure the speed of ultrasound ( SOS ) at the distal radius in 646 antiretroviral therapy ( ART )‐naïve HIV ‐infected women and 211 HIV ‐uninfected women. The Z ‐scores for SOS were based on data for women of the same age from the manufacturer's reference material. Results The mean CD 4 cell count was 285 (± 166) cells/μL in the HIV ‐positive women. SOS Z ‐scores adjusted and unadjusted for body mass index did not differ between the groups. SOS did not differ by CD 4 count (< 200 vs. ≥ 200 cells/μL: 4016 (± 117) vs. 4028 (± 107) m/s, respectively; p=0.19. Conclusions In HIV ‐positive ART ‐naïve Rwandan women with advanced HIV disease, bone quality at the distal radius was similar to that in HIV ‐negative controls.