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No correlation between statin exposure and incident diabetes mellitus in HIV ‐1‐infected patients receiving combination antiretroviral therapy
Author(s) -
Calza L,
Colangeli V,
Magistrelli E,
Manfredi R,
Bon I,
Re MC,
Viale P
Publication year - 2016
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12374
Subject(s) - medicine , hazard ratio , diabetes mellitus , incidence (geometry) , body mass index , confidence interval , statin , cohort , retrospective cohort study , cohort study , endocrinology , physics , optics
Objectives Recent clinical studies and one meta‐analysis have shown a modest but significant increase in the incidence of diabetes mellitus associated with statin exposure, so this correlation was investigated in a cohort of HIV ‐positive subjects. Methods A retrospective cohort study including adult HIV ‐1‐infected patients followed at our Clinic of Infectious Diseases between 2007 and 2014 was performed. Results We assessed 3170 HIV ‐positive patients with a median follow‐up of 5.2 years. The incidence of diabetes mellitus was 1.2 per 100 person‐years and it was not significantly associated with the prescription of statins [hazard ratio ( HR ) 1.09 per year of statin exposure; 95% confidence interval ( CI ) 0.7–1.49; P = 0.067], while it was associated with older age, chronic hepatitis C, antiretroviral‐naïve vs . antiretroviral experienced condition, high body mass index, and high serum concentration of triglycerides. Conclusions In our study, a higher risk of diabetes mellitus was not associated with statin treatment, but with some traditional risk factors.