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Opioid use and risk of liver fibrosis in HIV /hepatitis C virus‐coinfected patients in C anada
Author(s) -
Brunet L,
Moodie EEM,
Cox J,
Gill J,
Cooper C,
Walmsley S,
Rachlis A,
Hull M,
Klein MB
Publication year - 2016
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12279
Subject(s) - medicine , opioid , odds ratio , hepatitis c , hepatitis c virus , cohort , confidence interval , hazard ratio , cohort study , population , gastroenterology , immunology , environmental health , virus , receptor
Objectives Opioid use and opioid‐related mortality have increased dramatically since the 1990s in North America. The effect of opioids on the liver is incompletely understood. Some studies have suggested that opioids cause liver damage and others have failed to show any harm. HIV /hepatitis C virus ( HCV )‐coinfected persons may be particularly vulnerable to factors increasing liver fibrosis. We aimed to describe opioid use in an HIV / HCV ‐coinfected population in C anada and to estimate the association between opioid use and liver fibrosis. Methods We conducted a cross‐sectional descriptive analysis of the C anadian C o‐infection C ohort S tudy data to characterize opioid use. We then conducted a longitudinal analysis to assess the average change in aspartate aminotransferase‐to‐platelet ratio index ( APRI ) score associated with opioid use using a generalized estimating equation with linear regression. We assessed the progression to significant liver fibrosis ( APRI ≥ 1.5) associated with opioid use with pooled logistic regression. Results In the 6 months preceding cohort entry, 32% of the participants had received an opioid prescription, 28% had used opioids illicitly and 18% had both received a prescription and used opioids illicitly. Neither prescribed nor illicit opioid use was associated with a change in the median APRI score [exp(β) 0.99 (95% confidence interval ( CI ) 0.82, 1.12) and exp(β) 0.95 (95% CI 0.81, 1.10), respectively] or with faster progression to liver fibrosis [hazard odds ratio ( HOR ) 1.20 (95% CI 0.73, 1.67) and HOR 1.09 (95% CI 0.63, 1.55), respectively]. Conclusions Although opioids were commonly used both legally and illegally in our cohort, we were unable to demonstrate a negative impact on liver fibrosis progression.