z-logo
Premium
Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first‐line combination antiretroviral therapy
Author(s) -
Hattab S,
Guiguet M,
Carcelain G,
Fourati S,
Guihot A,
Autran B,
Caby F,
Marcelin AG,
Costagliola D,
Katlama C
Publication year - 2015
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/hiv.12257
Subject(s) - cart , medicine , biomarker , immune system , gastroenterology , inflammation , immunology , odds ratio , mechanical engineering , biochemistry , chemistry , engineering
Objectives The aim of the study was to assess the impact of rapid and sustained viral control produced by combination antiretroviral therapy (c ART ) on HIV ‐associated immune activation and inflammation. Methods In this longitudinal observational study, we examined changes in interleukin‐6 ( IL ‐6), interferon‐γ‐inducible protein‐10 ( IP ‐10), monokine induced by interferon‐γ ( MIG ) and soluble CD 14 (s CD 14) levels during 2 years of effective first‐line c ART . Biomarker levels before and after c ART were compared with those observed in healthy subjects, using the Wilcoxon signed rank test. Elevated biomarker levels were defined with respect to values for healthy subject (mean + 2 standard deviations). Factors associated with persistently elevated biomarker levels after 2 years of c ART were identified by logistic regression. Results We included in the study 139 patients with a median HIV ‐1 RNA level of 4.8 log 10 HIV ‐1 RNA copies/mL and a median CD 4 cell count of 294 cells/μL at c ART initiation [day 0 ( D 0)]. At D 0, all biomarker levels were higher than in healthy subjects ( P  < 0.05). After 2 years of c ART , IL ‐6, IP ‐10 and MIG levels fell significantly, by a median of 0.54, 420 and 1107 pg/mL, respectively (all P  < 0.001), and were no longer elevated in > 75% of patients. In contrast, s CD 14 levels did not change significantly (0.18 × 10 6  pg/mL; P  = 0.102) and remained elevated. Older age was associated with elevated levels of IP ‐10 [odds ratio ( OR ) 1.60 per 10 years older; P  = 0.047] and MIG ( OR 1.92 per 10 years older; P  = 0.007) after 2 years of c ART . Conclusions The rapid and sustained viral suppression produced by first‐line c ART reduced IL ‐6, IP ‐10 and MIG to normal levels, while s CD 14, a marker of monocyte activation, remained elevated. High levels of IP ‐10 and MIG tended to persist in older patients.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here