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Metaplastic carcinomas of the breast without evidence of epithelial differentiation: a diagnostic approach for management
Author(s) -
Rakha Emad A,
Quinn Cecily M,
Foschini Maria Pia,
Muñoz Martin Monica,
Dabbs David J,
Lakhani Sunil,
Varga Zsuzsanna,
Pinder Sarah E,
Schmitt Fernando C,
ReisFilho Jorge S,
Fox Stephen B,
Ellis Ian O,
Tan PuayHoon,
Mihai Raluca
Publication year - 2021
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14290
Subject(s) - metaplastic carcinoma , immunohistochemistry , pathology , medicine , breast tumours , carcinoma , breast carcinoma , not otherwise specified , oncology , breast cancer , cancer
Although rare, malignant sarcomatoid breast tumours without evidence of epithelial differentiation comprise a diagnostic challenge with management implications. Earlier studies have generally considered these to be primary breast sarcomas; however, supporting evidence is lacking and management remains variable. This study aimed to provide an evidence-based approach to improve the consistency of diagnosis and management for such cases.