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Taking tumour budding to the next frontier — a post International Tumour Budding Consensus Conference (ITBCC) 2016 review
Author(s) -
Studer Linda,
Blank Annika,
Bokhorst JohnMelle,
Nagtegaal Iris D,
Zlobec Inti,
Lugli Alessandro,
Fischer Andreas,
Dawson Heather
Publication year - 2021
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14267
Subject(s) - budding , tumor budding , consensus conference , budding yeast , tumour tissue , biology , pathology , medicine , cancer , metastasis , genetics , saccharomyces cerevisiae , gene , lymph node metastasis , biochemistry
Tumour budding in colorectal cancer, defined as single tumour cells or small clusters containing four or fewer tumour cells, is a robust and independent biomarker of aggressive tumour biology. On the basis of published data in the literature, the evidence is certainly in favour of reporting tumour budding in routine practice. One important aspect of implementing tumour budding has been to establish a standardised and evidence‐based scoring method, as was recommended by the International Tumour Budding Consensus Conference (ITBCC) in 2016. Further developments have aimed at establishing methods for automated tumour budding assessment. A digital approach to scoring tumour buds has great potential to assist in performing an objective budding count but, like the manual consensus method, must be validated and standardised. The aim of the present review is to present general considerations behind the ITBCC scoring method, and a broad overview of the current situation and challenges regarding automated tumour budding detection methods.