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Update on the pathology, genetics and somatic landscape of sebaceous tumours
Author(s) -
Ferreira Ingrid,
Wiedemeyer Katharina,
Demetter Pieter,
Adams David J,
Arends Mark J,
Brenn Thomas
Publication year - 2020
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14044
Subject(s) - sebaceous carcinoma , lynch syndrome , molecular pathology , pathology , medicine , differential diagnosis , colorectal cancer , carcinoma , cancer , biology , dna mismatch repair , genetics , gene
Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. The majority of tumours are solitary and sporadic, but a subset of tumours may be associated with Lynch syndrome, also known as hereditary non‐polyposis colon cancer (HNPCC) and previously referred to as Muir‐Torre syndrome (now known to be part of Lynch syndrome). This review provides an overview of the clinical and histological features of cutaneous sebaceous neoplasia with an emphasis on differentiating features and differential diagnosis. It also offers insights into the recently described molecular pathways involved in the development of sebaceous tumours and their association with Lynch syndrome.