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Expanding the clinicopathologic and molecular spectrum of BCOR ‐associated sarcomas in adults
Author(s) -
Yoshida Akihiko,
Arai Yasuhito,
Hama Natsuko,
Chikuta Hiroshi,
Bando Yoshimi,
Nakano Seiichi,
Kobayashi Eisuke,
Shibahara Junji,
Fukuhara Hiroshi,
Komiyama Motokiyo,
Watanabe Shunichi,
Tamura Kenji,
Kawai Akira,
Shibata Tatsuhiro
Publication year - 2020
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14023
Subject(s) - pathology , stroma , sarcoma , cdkn2a , population , biology , mesothelioma , immunohistochemistry , medicine , cancer research , cancer , environmental health
Aims BCOR gene alteration is a genetic signature of rare subsets of sarcomas. Most BCOR ‐associated sarcomas thus far reported are in the pediatric population, except for uterine sarcomas. We studied seven cases of BCOR ‐associated non‐uterine sarcomas in adult patients. Methods and results The patients were four men and three women ranging from 26 to 71 years in age. Three tumors, two of which primarily affected the kidney, showed BCOR‐CCNB3 . One tumor with a ZC3H7B‐BCOR occurred in the chest wall, and a tumor with a novel CIITA‐BCOR was found in the sinonasal tract. Two tumors in the lung and breast harbored exon 15 internal tandem duplications of BCOR , a highly unexpected observation in this age group. All seven sarcomas consisted of dense proliferations of uniform round to spindle cells with fine chromatin within vascular stroma. BCOR‐CCNB3 sarcomas showed swirling fascicular growth. The tumor with the ZC3H7B‐BCOR fusion showed a multinodular growth of spindle cells, and the tumors with the CIITA‐BCOR fusion showed palisading of oval cells. Both tumors with BCOR internal tandem duplication demonstrated nested to palisading growth of round cells within sclerotic non‐myxoid stroma. All seven sarcomas diffusely expressed BCOR and SATB2 immunohistochemically, with all three BCOR‐CCNB3 sarcomas being immunopositive for CCNB3. BCOR alterations were confirmed by RNA sequencing, polymerase chain reaction, Sanger sequencing, and/or fluorescence in situ hybridization. Conclusions This study expands the clinicopathologic and molecular spectrum of BCOR ‐associated sarcomas, and emphasizes the importance of being aware of this entity in the differential diagnosis of adult non‐uterine sarcomas.