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The role of glutaminase in cancer
Author(s) -
Masisi Brendah K,
El Ansari Rokaya,
Alfarsi Lutfi,
Rakha Emad A,
Green Andrew R,
Craze Madeleine L
Publication year - 2020
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14014
Subject(s) - glutaminase , glutaminolysis , glutamine , breast cancer , cancer , carcinogenesis , biology , isozyme , cancer research , cancer cell , enzyme , disease , suppressor , medicine , genetics , biochemistry , amino acid
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire glutamine metabolism to support survival and proliferation. Glutaminase isoenzymes (GLS and GLS2) are key enzymes for glutamine metabolism. Interestingly, GLS and GLS2 have contrasting functions in tumorigenesis. In this review, we explore the role of glutaminase in cancer, primarily focusing on breast cancer, address the role played by oncogenes and tumour suppressor genes in regulating glutaminase, and discuss current therapeutic approaches to targeting glutaminase.