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Novel TFG – RET fusion in a spindle cell tumour with S100 and CD34 coexpresssion
Author(s) -
Loong Shihleone,
Lian Derrick W Q,
Kuick Chik H,
Lim Tse H,
Nah Shireen A,
Wong Kenneth P L,
Chang Kenneth T E
Publication year - 2020
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13971
Subject(s) - cd34 , fusion , cancer research , microbiology and biotechnology , medicine , pathology , biology , stem cell , linguistics , philosophy
The classification of spindle cell tumours with monomorphic morphology and lacking a clear immunophenotype remains challenging. Recurrent fusions involving receptor tyrosine or cytoplasmic kinase genes have been described in various spindle cell tumours1-4 . Among these, spindle cell tumours with monomorphic morphology displaying distinct stromal and perivascular hyalinization and co-expressing S100 and CD34 can be grouped into an entity featuring recurrent fusions involving RAF1, BRAF and NTRK1/2 genes2 . A case with similar morphology showing NCOA4-RET fusion was also described recently5 . In this report, we describe a case occurring in a child in which a novel gene fusion TFG-RET was identified. This article is protected by copyright. All rights reserved.