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Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases
Author(s) -
Soares Ciro D,
Morais Thayná M L,
Carlos Roman,
Jorge Jacks,
Almeida Oslei Paes,
Carvalho Maria G F,
Altemani Albina M M
Publication year - 2018
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13664
Subject(s) - pathology , sebaceous carcinoma , cd34 , immunohistochemistry , sebaceous gland , adenocarcinoma , medicine , metastasis , salivary gland , vimentin , biology , carcinoma , cancer , stem cell , genetics
Aims Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri‐ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. Methods and results We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31–90) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins ( AE 1 AE 3 and CK ‐5), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor XIII a, S‐100, vimentin and perforin. MLH 1 and MSH 2 were expressed in the nuclei of most tumour cells, and one case showed loss of MSH 2 expression. Proliferative index (assessed by Ki‐67 expression) and microvessel density ( CD 34‐positive vessels) were higher in metastasis‐associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity. Conclusions The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool.