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MDM 2 expression in the progression of Barrett's oesophagus
Author(s) -
Robinson Leora,
Ilyas Mohammad,
Ragunath Krish,
Card Tim,
AbraduBerchie Berice,
Kaye Philip
Publication year - 2018
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13480
Subject(s) - nottingham health profile , university hospital , medicine , general hospital , library science , family medicine , alternative medicine , computer science , pathology
Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1 . There is however still a need for additional early stage markers. This article is protected by copyright. All rights reserved.