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Combined loss of HLA I and HLA II expression is more common in the non‐ GCB type of diffuse large B cell lymphoma
Author(s) -
Meeren Lotte E,
Visser Lydia,
Diepstra Arjan,
Nijland Marcel,
Berg Anke,
Kluin Philip M
Publication year - 2018
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13445
Subject(s) - lymphoma , immunohistochemistry , diffuse large b cell lymphoma , human leukocyte antigen , germinal center , medicine , follicular lymphoma , pathology , antigen , immunology , b cell , antibody
As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.