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Insulin‐like growth factor II messenger RNA ‐binding protein‐3 is an independent prognostic factor in uterine leiomyosarcoma
Author(s) -
Yasutake Nobuko,
Ohishi Yoshihiro,
Taguchi Kenichi,
Hiraki Yuka,
Oya Masafumi,
Oshiro Yumi,
Mine Mari,
Iwasaki Takeshi,
Yamamoto Hidetaka,
Kohashi Kenichi,
Sonoda Kenzo,
Kato Kiyoko,
Oda Yoshinao
Publication year - 2018
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13422
Subject(s) - univariate analysis , immunohistochemistry , growth factor , receptor , messenger rna , medicine , insulin like growth factor , biology , cancer research , endocrinology , oncology , multivariate analysis , gene , genetics
Aims The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma ( ULMS ). Methods and results We reviewed 60 cases of surgically resected ULMS s and investigated conventional clinicopathological factors, together with the expression of insulin‐like growth factor II messenger RNA ‐binding protein‐3 ( IMP 3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 ( MED 12 ) mutation analysis was also performed. Univariate analyses revealed that advanced stage ( P < 0.0001), older age ( P = 0.0244) and IMP 3 expression ( P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage ( P < 0.0001) and IMP 3 ( P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED 12 mutations (12% in ULMS s) were not identified as prognostic markers in this study. Conclusions IMP 3 expression in ULMS could be a marker of a poor prognosis.