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Response to Park et al . reply to ‘Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II / III colon cancer in a large population‐based study’
Author(s) -
Hynes Seán O,
Coleman Helen G,
Kelly Paul J,
Dunne Philip D,
SaltoTellez Manuel,
Loughrey Maurice B
Publication year - 2017
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.13221
Subject(s) - northern ireland , medicine , library science , gerontology , pathology , history , ethnology , computer science
We thank Park et al for their interest in our work and for bringing to our attention their alternative microenvironmental score for assessing colorectal cancer prognosis. 1-3 We are largely in agreement with many of the points raised. The scoring systems proposed by these two studies share many similarities, highlighting the importance of the non-epithelial tumour components and combining assessments of peritumoral inflammatory response and tumour stromal percentage to derive a prognostically valuable fibroinflammatory or microenvironmental score. Despite the overall similarity, a number of small, albeit clinically important, differences lie in the methodologies chosen for assessment of each individual parameter, and in the statistical approaches used. This article is protected by copyright. All rights reserved.