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Novel insights into the early histopathogenesis of immunodeficiency‐associated Burkitt lymphoma: a case report of Burkitt microlymphoma arising within HIV lymphadenitis
Author(s) -
Park David,
Ozkaya Neval,
Hariharan Aparna
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12960
Subject(s) - lymphoma , pathology , immunohistochemistry , epstein–barr virus , medicine , virology , virus
Aims To report a case detailing the early histopathogenesis of Burkitt lymphoma ( BL ), Epstein‐Barr virus ( EBV ) positive, in the clinical setting of HIV infection. Methods and results We describe a 57 year‐old woman with newly diagnosed HIV infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed EBV ‐positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B‐cell areas of HIV lymphadenitis. Due to positron emission tomography/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence in situ hybridization, and flow cytometric analyses confirmed BL . Conclusions Early histopathogenesis of HIV ‐associated BL occurred as nests of EBV ‐positive Burkitt cells within prominent monocytoid B‐cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and BL .