Germ cell neoplasia  in situ  ( GCNIS ): evolution of the current nomenclature for testicular pre‐invasive germ cell malignancy | Zendy

Berney Daniel M | Zendy; Looijenga Leendert H J | Zendy; Idrees Muhammad | Zendy; Oosterhuis J Wolter | Zendy; RajpertDe Meyts Ewa | Zendy; Ulbright Thomas M | Zendy; Skakkebaek Niels E | Zendy

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Germ cell neoplasia in situ ( GCNIS ): evolution of the current nomenclature for testicular pre‐invasive germ cell malignancy

Author(s) -

Berney Daniel M,

Looijenga Leendert H J,

Idrees Muhammad,

Oosterhuis J Wolter,

RajpertDe Meyts Ewa,

Ulbright Thomas M,

Skakkebaek Niels E

Publication year - 2016

Publication title -

histopathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.626

H-Index - 124

eISSN - 1365-2559

pISSN - 0309-0167

DOI - 10.1111/his.12958

Subject(s) - germ cell , malignancy , carcinoma in situ , germ , germ cell tumors , biology , in situ , cell , pathology , medicine , microbiology and biotechnology , chemistry , carcinoma , genetics , chemotherapy , gene , organic chemistry

The pre‐invasive lesion associated with post‐pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow‐up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed ‘carcinoma in situ ’ ( CIS ), it has also been known as ‘intratubular germ cell neoplasia, unclassified’ ( IGCNU ) and ‘testicular intraepithelial neoplasia’ ( TIN ). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization ( WHO ) consensus classification 2016: germ cell neoplasia in situ ( GCNIS ).

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