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Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation
Author(s) -
Quaglia Alberto,
Alves Venancio A,
Balabaud Charles,
Bhathal Prithi S,
BioulacSage Paulette,
Crawford James M,
Dhillon Amar P,
Ferrell Linda,
Guido Maria,
Hytiroglou Prodromos,
Nakanuma Yasuni,
Paradis Valerie,
Snover Dale C,
Theise Neil D,
Thung Swan N,
Tsui Wilson M S,
Leeuwen Dirk J
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12957
Subject(s) - cirrhosis , hepatocellular carcinoma , etiology , disease , medicine , liver disease , liver biopsy , pathology , chronic liver disease , biopsy , intensive care medicine
Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes. The old paradigm of ‘irreversibility’ of cirrhosis had been challenged in major ways, and the validity of the usage of the term ‘cirrhosis’ has come into question. This paper addresses aetiology‐based clinicopathological concepts and features that may deserve attention because they may determine disease outcome and, specifically, patterns of regression and remodelling. A variety of therapeutic interventions may influence remaining disease features after elimination of damaging agents (virus, alcohol, etc.), and determine the final clinical outcome including the risk of hepatocellular carcinoma ( HCC ). New concepts create new responsibilities and opportunities for the pathologist to contribute to the understanding of liver pathology and communicate this with clinical colleagues and researchers.