Premium
Overexpression of eukaryotic initiation factor 5A2 (EIF5A2) is associated with cancer progression and poor prognosis in patients with early‐stage cervical cancer
Author(s) -
Yang ShanShan,
Gao Ying,
Wang DeYing,
Xia BaiRong,
Liu YunDuo,
Qin Yu,
Ning XiaoMing,
Li GenYing,
Hao LiXiao,
Xiao Min,
Zhang YunYan
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12933
Subject(s) - stage (stratigraphy) , medicine , immunohistochemistry , cancer , cervical cancer , hazard ratio , oncology , pathology , confidence interval , biology , paleontology
Aims As one of the only two isoforms of the eukaryotic initiation factor ( EIF )5A family, EIF 5A2 plays an important role in tumour progression and prognosis evaluation. The aim of this study was to investigate EIF 5A2 expression in International Federation of Gynecology and Obstetrics ( FIGO ) stage I– II cervical cancer and to evaluate its clinical significance. Methods and results The mRNA and protein expression levels of EIF 5A2 were analysed in 20 tissue samples of FIGO stage I– II cervical cancer and paired surrounding non‐tumour cervical tissues by real‐time polymerase chain reaction and western blot analysis. Immunohistochemistry was performed to examine EIF 5A2 protein expression in paraffin‐embedded tissues from 314 patients with cervical cancer. The mRNA and protein expression levels of EIF 5A2 were significantly elevated in tumour tissues. The increased EIF 5A2 expression was correlated with higher FIGO stage ( P < 0.001), deep cervical stromal invasion ( P = 0.026), lymphovascular space involvement ( P = 0.002), pelvic lymph node metastasis ( P < 0.001) and postoperative recurrence ( P < 0.001) in patients with cervical cancer. Patients with tumours showing high EIF 5A2 expression had a poorer survival time than those with normal EIF 5A2 expression, especially the patients with negative pelvic lymph nodes and FIGO stage II . In addition, multivariate Cox analysis showed that high EIF 5A2 expression was an independent prognostic factor for overall survival [hazard ratio 1.949; 95% confidence interval ( CI ) 1.116–3.404; P = 0.019] and disease‐free survival (hazard ratio 1.980; 95% CI 1.189–3.297; P = 0.009). Conclusions EIF 5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF 5A2 could be a novel potential prognostic marker for FIGO stage I–II cervical cancer.