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FoxP3‐positive T cell lymphoma arising in non‐HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL‐NOS and 2 cases of mycosis fungoides
Author(s) -
Satou Akira,
Asano Naoko,
Kato Seiichi,
Katsuya Hiroo,
Ishitsuka Kenji,
Elsayed Ahmed A,
Nakamura Shigeo
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12885
Subject(s) - mycosis fungoides , lymphoma , medicine , not otherwise specified , peripheral t cell lymphoma , epstein–barr virus , foxp3 , cutaneous t cell lymphoma , pathology , t cell lymphoma , gastroenterology , immunology , t cell , virus , immune system
Aims Forkhead box protein 3‐positive (FoxP3 + ) T cell lymphoma, in the absence of human T cell lymphotrophic virus type 1 ( HTLV ‐1) infection, is rare and its clinicopathological characteristics still remain unclear. The aim of this study was to elucidate its characteristics. Methods and results We describe here 11 cases of peripheral T cell lymphoma not otherwise specified ( PTCL ‐ NOS ) and two cases of mycosis fingoides ( MF ) which were positive for FoxP3. The median age of the 11 PTCL ‐ NOS cases was 65 years (range: 48–80 years), and all the patients were male. Eight patients (80%) showed stages III / IV disease, and six (60%) were categorized as high–intermediate/high‐risk groups according to the International Prognostic Index. Two cases of MF were 57‐ and 59‐year‐old males. Both cases were categorized as stage IA , according to International Society for Cutaneous Lymphomas/European Organization of Research and Treatment of Cancer ( ISCL / EORTC ) classification. Immunohistochemically, all the cases were negative for cytotoxic molecule marker, and nine (75%) were αβ T cell type. Scattered Epstein–Barr virus ( EBV )‐infected cells were detected in four cases of PTCL ‐ NOS , implying the reactivation of EBV caused by the immunodeficient status of the patients. Conclusions FoxP3 + PTCL ‐ NOS constitute a minor phenotypical subtype with poor prognosis and EBV reactivation in some. Conversely, two cases of MF showed an indolent clinical course which was different from previously reported cutaneous T cell lymphoma ( CTCL ) cases.