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Organizing pneumonia components in non‐specific interstitial pneumonia ( NSIP ): a clinicopathological study of 33 NSIP cases
Author(s) -
Huo Zhen,
Li Ji,
Li Shanqing,
Zhang Haibo,
Jin Zhengyu,
Pang Junyi,
Liu Hongrui,
Shi Juhong,
Feng Ruie
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12761
Subject(s) - pathological , pathology , medicine , lung , pneumonia , organizing pneumonia , lung biopsy , biopsy , interstitial pneumonia , idiopathic interstitial pneumonia
Aims To review the clinical, radiological and pathological features of non‐specific interstitial pneumonia ( NSIP ), mainly to characterize organizing pneumonia ( OP ) components in NSIP . Methods and results Lung biopsy samples from 33 NSIP patients were collected over a period of 10 years. Microscopic analysis revealed that 13 cases showed a cellular pattern and 20 showed a mixed/fibrosing pattern. OP components were detected in 26 cases (13 with a cellular pattern; 13 with a mixed/fibrosing pattern), and were found to constitute a median proportion of 9% (range, 1–40%) of the affected tissues. In nine cellular and four mixed/fibrosing NSIP cases, the OP components accounted for ≥10%. A proportion of ≥20% was found in only five cellular pattern cases. Twenty‐nine patients were followed up: 17 showed improvements, five were stabilized, and seven showed progression. Conclusions OP components are common basic lesions in NSIP cases, although their proportion in cellular and mixed/fibrosing pattern cases varies substantially between patients. OP components do not impact on prognosis, even when they constitute ≥20% of the affected tissue. Thus, a high level of OP components does not exclude a diagnosis of NSIP in cases that otherwise show pathological and radiological findings characteristic of NSIP .