Premium
Cutaneous inflammatory myofibroblastic tumours can be anaplastic lymphoma kinase‐positive: report of the first four cases
Author(s) -
Leguellec Sophie,
Tournier Emilie,
Karanian Marie,
Brousset Pierre,
Mazereeuw Juliette,
Coindre JeanMichel,
Lamant Laurence
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12759
Subject(s) - anaplastic lymphoma kinase , pathology , immunohistochemistry , anaplastic large cell lymphoma , myofibroblast , medicine , dermis , lymphoma , soft tissue , cd68 , fluorescence in situ hybridization , differential diagnosis , biology , lung cancer , fibrosis , biochemistry , gene , malignant pleural effusion , chromosome
Aims Inflammatory myofibroblastic tumours ( IMT s) usually have a soft tissue and visceral localization, but have been rarely reported in skin. The aim of this study was to characterize the histological and immunohistochemical features of a series of cutaneous IMT s. Methods and results We retrieved from our archives over 10 years four cutaneous IMT s; one was diagnosed in a child, and three in young adults. Tumours were centred on the dermis, and also involved the subcutis in two cases. Two of them corresponded to the ‘myxoid–vascular’ pattern of IMT , whereas the others were characterized by compact fascicles of spindle‐shaped cells. They stained positively for smooth muscle actin. All samples stained positively for anaplastic lymphoma kinase ( ALK ). ALK expression was limited to the cytoplasm of myofibroblasts and, in the three investigated cases, correlated with ALK rearrangement as shown by fluorescence in‐situ hybridization analysis. Conclusions This is the first report of ALK ‐positive IMT s with a cutaneous localization. Because of their morphological heterogeneity and low incidence in skin, the diagnosis of cutaneous IMT s is often challenging. A cutaneous spindled cell tumour associated with an inflammatory infiltrate should prompt pathologists to perform ALK staining, which, if positive, might be decisive for diagnosis.