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Pleomorphic adenoma‐like tumour of the breast
Author(s) -
Rakha Emad A,
Aleskandarany Mohammed A,
Samaka Rehab M,
Hodi Zsolt,
Lee Andrew H S,
Ellis Ian O
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12757
Subject(s) - myoepithelial cell , pathology , pleomorphic adenoma , metaplastic carcinoma , stroma , biopsy , immunohistochemistry , medicine , adenoma , carcinoma , lesion , biology , breast cancer , salivary gland , cancer
Aims Pleomorphic adenoma ( PA ) of the breast is a rare tumour seen usually in postmenopausal women. Although PA of the salivary glands ( SG ) is recognized to be a benign tumour, the nature and biology of similar tumours seen in the breast remains to be defined. The aim of this study was to describe PA of the breast that was reported on core biopsy as an invasive matrix‐producing metaplastic breast carcinoma ( MBC ). Methods and results A core biopsy from a clinically malignant retroareolar mass showed mildly atypical polygonal cells with surrounding myxoid stroma. Immunohistochemistry showed expression of basal and luminal cytokeratins, but oestrogen receptor, human epidermal growth factor receptor 2 ( HER 2) and myoepithelial markers were negative. The excision specimen showed similar features, but in addition the stroma showed cartilage and bone. Also it was clear that the lesion was circumscribed and merged with a sclerosed papillary lesion consistent with what has been described as mammary PA . Conclusion This lesion shows an overlap of morphology and immunophenotype with SG ‐ PA and with MBC . The majority of mammary PA s have a benign behaviour, but local recurrence and development of carcinoma occur. We propose a new terminology of pleomorphic adenoma‐like tumour of the breast to reflect the uncertain nature of these tumours and help guide management decisions.