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The role of CD 5 expression in thymic carcinoma: possible mechanism for interaction with CD 5 + lymphoid stroma (microenvironment)
Author(s) -
Hosaka Naoki,
Ohe Chisato,
Miyasaka Chika,
Nakano Yorika,
Sakaida Noriko,
Uemura Yoshiko,
Saito Yukihito,
Ikehara Susumu,
Tsubura Airo,
Takahashi Hakuo
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12742
Subject(s) - thymic carcinoma , cd5 , stroma , biology , pathology , carcinoma , immunohistochemistry , antigen , cancer research , thymoma , immunology , medicine
Aims Most thymic carcinomas express the lymphocyte marker CD 5 aberrantly. This study was performed to examine the role of the self‐reactive CD 5 antigen in thymic carcinoma. Methods and results We examined CD 5 expression in thymic carcinoma in relation to the lymphoid stroma. All cases of thymic carcinoma examined expressed CD 5. A number of CD 5 + lymphocytes were also present in the stroma of thymic carcinoma. The CD 5 + tumour areas were predominantly in contact with the lymphoid stroma, and the expression level was significantly lower in tumour cells than lymphocytes. Although p53 and B cl‐2 expression levels were significantly higher in thymic carcinoma than normal thymic epithelial cells ( TEC s), they did not differ between CD 5 + and CD 5 − areas. E‐cadherin expression in thymic carcinoma was comparable with that of normal TEC s, and it also did not differ between these areas. In contrast, both K i‐67 index and mitotic activity were significantly higher in thymic carcinoma than normal TEC s, and they were significantly higher in CD 5 + than CD 5 − areas. Conclusions CD 5 may be induced by interaction with CD 5 + lymphoid stroma, and may be related to tumour proliferation. CD 5 induction may also be a significant and/or specific effect of the tumour microenvironment of the thymus.