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Low expression of B‐cell‐associated protein 31 in human primary hepatocellular carcinoma correlates with poor prognosis
Author(s) -
Tan Ning,
Liu Qinyi,
Liu Xiaojia,
Gong Zhiwei,
Zeng Yonglian,
Pan Guangdong,
Xu Qing,
He Songqing
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12738
Subject(s) - tissue microarray , immunohistochemistry , hepatocellular carcinoma , cohort , medicine , oncology , pathology , multivariate analysis
Aims The aim of the present study was to investigate the prognostic value of B‐cell associated protein 31 ( BAP 31) in human primary hepatocellular carcinoma ( HCC ). Methods and results BAP 31 levels were evaluated by immunohistochemistry on tissue microarrays. The integral optical density, representing the expression level of BAP 31 in each tissue sample, was calculated with image ‐ pro plus . Immunohistochemical analysis of BAP 31 levels in 74 paired HCC tissues and peritumoral non‐cancerous tissues showed that BAP 31 expression was significantly higher in HCC tumour tissues ( P = 0.025). The prognostic value of BAP 31 in HCC was evaluated in 234 cases in a training cohort and in 63 cases in a validation cohort. The expression level of BAP 31 was significantly correlated with overall survival ( OS ) in both the training cohort and the validation cohort. The lower the level of BAP 31 expression in HCC tissue, the poorer the prognosis. Univariate and multivariate analyses showed that the expression level of BAP 31 in HCC was an independent prognostic factor for OS in both the training cohort and the validation cohort. Conclusions BAP 31 expression is an independent prognostic factor for OS of patients with postoperative HCC , and low expression levels of BAP 31 in HCC may indicate poor outcomes of HCC patient after surgical resection.