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Prognostic value of chromosomal translocations in small‐bowel diffuse large B‐cell lymphoma
Author(s) -
Ikegami Koji,
Nakamura Shotaro,
Esaki Motohiro,
Yanai Shunichi,
Hirahashi Minako,
Oda Yoshinao,
Takeshita Morishige,
Matsumoto Takayuki,
Kitazono Takanari
Publication year - 2016
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12731
Subject(s) - chromosomal translocation , fluorescence in situ hybridization , lymphoma , univariate analysis , medicine , international prognostic index , immunoglobulin heavy chain , diffuse large b cell lymphoma , biology , pathology , oncology , cancer research , multivariate analysis , antibody , immunology , gene , chromosome , genetics
Aims The objective of this study was to investigate the incidence and clinical significance of lymphoma‐associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene ( IGH ) locus, in patients with small‐bowel diffuse large B‐cell lymphoma ( DLBCL ). Methods and results Translocations involving IGH , bcl‐6 , MYC and bcl‐2 were investigated with interphase fluorescence in‐situ hybridization on paraffin‐embedded tissues in 35 patients with primary small‐bowel DLBCL , and the overall survival ( OS ) and progression‐free survival ( PFS ) rates were evaluated with the Kaplan–Meier method. Translocations involving IGH , bcl‐6 , MYC and bcl‐2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH , extra copies of MALT 1 / bcl‐2 and bcl‐6 immunoexpression were significantly associated with better OS and PFS . Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS , but not better OS . Conclusions Translocations involving IGH are frequent in cases of small‐bowel DLBCL . These translocations may be predictive of a favourable clinical course.