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The expression of astrocyte elevated gene‐1 in human non‐small‐cell lung cancer and its relationship with postoperative chemotherapy and radiotherapy
Author(s) -
Lu Shan,
Xu Jianyu,
Xu Xiangying,
Hu Songliu,
Li Bin,
Li Wenxin
Publication year - 2015
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12720
Subject(s) - radiation therapy , chemotherapy , medicine , lung cancer , oncology , immunohistochemistry , pathological , stage (stratigraphy) , lymph node , multivariate analysis , pathology , biology , paleontology
Aims To examine the expression of astrocyte elevated gene‐1 ( AEG ‐1) in non‐small‐cell lung cancer ( NSCLC ) and analyse the correlation between AEG ‐1 expression and the prognosis of the patients, particularly the relationship between AEG ‐1 expression and postoperative chemotherapy and radiotherapy. Methods The expression of AEG ‐1 was analysed by immunohistochemistry in 225 primary NSCLC specimens and 42 adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the correlation between AEG ‐1 expression and the clinicopathological characteristics of the patients as well as the predictive value of AEG ‐1. Results The expression of AEG ‐1 was associated with the pathological stage ( P < 0.001) and lymph node status ( P = 0.028). A multivariate analysis indicated that AEG ‐1 expression was an independent prognostic factor for both overall survival ( OS ) and disease‐free survival ( DFS ). In the postoperative chemotherapy group, the OS ( P = 0.014) and DFS ( P = 0.009) in the low AEG ‐1 expression group were longer than the survival times in the high AEG ‐1 expression group. In the postoperative radiotherapy group, the local recurrence‐free survival was significantly shorter in patients whose tumours showed high AEG ‐1 expression ( P = 0.016). Conclusions AEG ‐1 expression could be a predictor for OS and DFS in NSCLC patients. Patients with low AEG ‐1 expression received the greatest benefit from both postoperative chemotherapy and radiotherapy.