Premium
Bombesin staining in neuroendocrine cell hyperplasia of infancy ( NEHI ) and other childhood interstitial lung diseases (ch ILD )
Author(s) -
Yancheva Slaveya G,
Velani Asha,
Rice Alexandra,
Montero Angeles,
Hansell David M,
Koo Sergio,
Thia Lina,
Bush Andrew,
Nicholson Andrew G
Publication year - 2015
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12672
Subject(s) - medicine , bombesin , interstitial lung disease , airway , lung , neuroendocrine cell , pathology , hyperplasia , gastroenterology , etiology , immunohistochemistry , endocrinology , receptor , surgery , neuropeptide
Aims We have analysed levels of bombesin‐positive neuroendocrine cells ( NEC s) in neuroendocrine cell hyperplasia of infancy ( NEHI ) and other childhood interstitial lung diseases (ch ILD s) in order to validate proposed histological criteria for NEHI and investigate its aetiology. Methods and results The extent of bombesin‐positive cells within airway epithelium was analysed in lung biopsies from seven patients diagnosed with NEHI , including two classified previously as non‐diagnostic, and other ch ILD s ( n = 64) with age ranges of 1 month–18 years. NEC s were counted and calculated as a percentage of airways containing NEC s, average percentage of NEC s per airway, percentage of airways with >10% NEC s and number of neuroendocrine bodies ( NEB s). Correlation with age and gender was also undertaken. Patients with NEHI had the highest average percentage of bombesin‐positive NEC s per airway compared to other ch ILD s. However, NEH was also seen in many other ch ILD s, and appears to be most prominent in disorders associated with lung immaturity such as histological patterns associated with surfactant protein‐related disorders and pulmonary interstitial glycogenosis. Conclusions NEH may, to a degree, be a marker of airway immaturity rather than the direct cause of NEHI . This possibility is supported by the fact that the number of bombesin‐positive NEC s decreased with age in this cohort, independent of disease type. The average percentage of bombesin‐positive NEC s per airway appears to be the best histological criterion for assessing the extent of NEC s in the context of NEHI .