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GATA ‐binding protein 3, gross cystic disease fluid protein‐15 and mammaglobin have distinct prognostic implications in different invasive breast carcinoma subgroups
Author(s) -
Ni Yun Bi,
Tsang Julia Y S,
Chan Siu Ki,
Tse Gary M
Publication year - 2015
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12625
Subject(s) - mammaglobin , medicine , oncology , breast carcinoma , carcinoma , cancer research , breast cancer , cancer
Aims To evaluate the prognostic significance of GATA ‐binding protein 3 ( GATA ‐3), gross cystic disease fluid protein‐15 ( GCDFP ‐15) and mammaglobin ( MGB ) in invasive breast carcinomas ( IBC s). Methods and results GATA ‐3, GCDFP ‐15 and MGB were expressed in 37.9% (370/976), 26.0% (254/978) and 35.3% (348/986) of this cohort of 1017 IBC s, respectively. GCDFP ‐15 was an independent favourable prognostic factor in all cases [disease‐free survival ( DFS ), hazard ratio ( HR ) 0.587, P = 0.049; overall survival ( OS ), HR 0.512, P = 0.049], as well as in oestrogen receptor ( ER )‐negative ( DFS , HR 0.353, P = 0.012; OS , HR 0.310, P = 0.017) and HER 2‐positive ( DFS , HR 0.279, P = 0.036; OS , HR 0.235, P = 0.050) cases; it also refined the prognostication of molecular apocrine cancers. GATA ‐3 and MGB did not show any prognostic significance. Conclusions The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP ‐15 independently indicated a favourable prognosis, especially in ER ‐negative, HER 2‐positive and molecular apocrine cancers. GATA ‐3 and MGB were not associated with outcome.