Premium
Granular cell tumours of the colorectum: histopathological and immunohistochemical evaluation of 30 cases
Author(s) -
Na JongIn,
Kim HyeJeong,
Jung JongJae,
Kim Young,
Kim SungSun,
Lee JaeHyuk,
Lee KyungHwa,
Park JongTae
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12487
Subject(s) - synaptophysin , immunohistochemistry , pathology , nuclear atypia , medicine
Aims Granular cell tumours ( GCT s) are uncommon in the gastrointestinal tract, particularly in the colorectum. Herein, we report a series of 30 colorectal GCT s and discuss the properties of colorectal GCT s based on histopathological and immunohistochemical studies. Methods and results Searching the surgical pathology files identified 30 cases of colorectal GCT s for 2005–2013. A broad panel of antibodies including neural and macrophage markers were used for immunohistochemical evaluation. Colorectal GCT s predominantly involved the right colon and showed increased nuclear atypia including nuclear pleomorphism and nuclear spindling. All 24 cases with mucosal tumour components had infiltrative growth patterns within the mucosa. In all available cases, diffuse strong immunopositivity was observed for S100 and SOX 10 of schwannian differentiation markers, as well as for CD 68. Other neuronal lineage markers, including CD 56, neuron‐specific enolase, nestin, and synaptophysin showed consistently high expression rates. The immunohistochemical results are suggestive for a neural origin of GCT s. Conclusion Histopathological and immunohistochemical features of colorectal GCT s were delineated in this large series of 30 colorectal GCT s. Although the incidence of GCT s is relatively low, clinicians and pathologists need to be aware of GCT in the differential diagnosis.