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Differential expression of IMP 3 between male and female mature teratomas—immunohistochemical evidence of malignant nature
Author(s) -
Goodman Steven,
Zhang Liping,
Cheng Liang,
Jiang Zhong
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12409
Subject(s) - immunohistochemistry , teratoma , biology , immunostaining , pathology , germ cell tumors , differential diagnosis , germ cell , seminoma , medicine , gene , chemotherapy , biochemistry , genetics
Aims Ovarian mature teratoma is a benign tumour, whereas mature teratoma in adult testicular germ cell tumours ( TGCT s) is considered to be a malignant tumour. IMP3, an oncofetal protein, plays an important role in embryogenesis and carcinogenesis. IMP3 has been demonstrated to be a malignant biomarker that is mainly expressed in malignant neoplasms rather than benign tissues. The aim of this study was to analyse IMP 3 expression in germ cell tumours, and compare its expression between male and female teratomas. Methods and results One hundred and seventy‐eight cases (62 TGCT s, 52 ovarian teratomas, 27 metastatic testicular teratomas, and 37 cases of normal testicular tissue) obtained from the archives of two large academic medical centres were examined for IMP 3 expression. Of the 62 TGCT s, 30 had mature teratoma components. IMP3 expression was present in 100% (30/30) of testicular mature teratoma components, and in 96% (26/27) of metastatic testicular teratomas. Other TGCT components also expressed IMP 3 in 99% of cases (78/79). IMP3 expression was negative in all female mature teratomas. Conclusions We describe for the first time an immunostaining marker that has differential expression in male and female mature teratomas, indicating that their pathogenesis differs. High expression of IMP 3 in adult mature testicular teratomas supports their malignant nature.